Hello, I was more encouraged by your post than I have been in a long time. However, 3 areas that need some discussion. First of all, there is significant evidence that SNPS exist in the Nrf2 which may be population specific and may not only influence MCS but also other environmental conditions such as CFS. Many of the supplements/nutritionals described here have the ability to activate the antioxidant system. Marzec demonstrates that SNPs in the NRF2 increases susceptibility to problems associated with oxidative stress and also makes it difficult to adequately control cytokine production. The reduction in Tregs have also recently been shown to increase asthmatic symptoms and make it more difficult to control inflammatory reactions from air pollution. There is a communication pathway that exists to the Nrf2 through the aryl hydrocarbon receptors that activates after exposures to them....Although not fully understood yet is there is an important connection between Tregs and the AhR that when altered may increase reactions to chemicals. Many flavonoids will bind the AhR in a different way than dioxins. SNPs in the AhR and the Nrf2 were not addressed in the polymorphism study that was mentioned. Abnormal methylation also may be a major factor and in many cases, chemicals impair regulation and increases insulin resistance that can lead to diabetes. It is worth noting some of the symptoms of MCS would be consistent with insulin resistance.
HEIRS Health
www.heirs-online.com
Read the Article at HuffingtonPost
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